Cancer & OncologyA Nature Medicine phase 1 trial found that a personalized neoantigen vaccine generated tumor-specific immune responses in ovarian cancer, with biomarker evidence of biologic activity in 6 of 10 vaccinated patients.
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Clinical Research & TrialsIn a 10-person NEJM study, optogenetic gene therapy increased light sensitivity in 7 people with advanced retinitis pigmentosa, including clinically meaningful improvement in 6.
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Cell & Molecular BiologyAlexander disease begins with toxic GFAP buildup in astrocytes. Here is how mutations create Rosenthal fibers, disrupt brain support cells, and led to antisense treatment.
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Cancer & OncologyESR1 mutations can keep estrogen receptor signaling active without estrogen, driving resistance to aromatase inhibitors in advanced breast cancer.
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Genetics & GenomicsThe gene-editing tool that's already curing some diseases — and its real limits.
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