Cancer & OncologyCirculating tumor DNA (ctDNA) testing can identify molecular signs of colorectal cancer recurrence after surgery, but a randomized phase 3 trial published in Nature Medicine in June 2026 found that treating patients solely because their blood test became positive did not significantly improve disease-free survival. In the ALTAIR trial, 243 patients with detectable tumor DNA […]
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Cancer & OncologyKRAS mutations drive more than 90% of pancreatic ductal adenocarcinomas (PDAC), yet the protein resisted direct drug development for decades because its surface offered few stable pockets for small molecules and because the mutant protein cycles between active and inactive conformations. That biology is now clinically relevant: a phase 3 trial published in The New […]
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Cardiovascular HealthHepcidin controls how iron moves through the body. In polycythemia vera, that makes iron restriction a way to reduce excess red blood cell production.
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Cancer & OncologyOral SERDs degrade the estrogen receptor and are changing treatment for ESR1-mutated breast cancer. Here is how they differ from aromatase inhibitors, tamoxifen, and fulvestrant.
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Cancer & OncologyCDK4/6 inhibitors slow HR-positive breast cancer by blocking a cell-cycle checkpoint. Here is how palbociclib, ribociclib, and abemaciclib work and how resistance develops.
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Cancer & OncologyLiquid biopsy can detect circulating tumor DNA in blood to reveal tumor mutations, treatment resistance, and molecular residual disease, but negative results have important limits.
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Cancer & OncologyESR1 mutations can keep estrogen receptor signaling active without estrogen, driving resistance to aromatase inhibitors in advanced breast cancer.
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Cancer & OncologyA personalized mRNA neoantigen therapy from Moderna and Merck met both major Phase 3 efficacy endpoints in resected high-risk melanoma, but the size of the benefit is not yet public.
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Precision MedicineWhy researchers increasingly hunt for new uses of drugs we already have.
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