Cell & Molecular BiologyA PLOS Biology study found that oligodendrocytes use the mechanosensitive channel Piezo1 to match myelin sheath length to axon diameter.
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Cancer & OncologyA Cancer Cell study found that brain-seeding cancer cells enter an MXD4-dependent proliferative pause that helps them survive early colonization and may expose a new therapeutic vulnerability.
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Cardiovascular HealthA Circulation Research study found that protective CD8+ regulatory T cells restored Notch signaling in vascular smooth muscle cells and slowed atherosclerosis in mice.
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Cell & Molecular BiologyA Neuron study identified a direct amygdala-to-dorsolateral-striatum pathway that strengthens cue-driven grooming and is abnormally active in a mouse model of compulsive behavior.
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Cancer & OncologyA new Nature Communications study identified MPZL1 as a potential CAR-T target in solid tumors and showed tumor regression in multiple preclinical models.
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Cancer & OncologyAn Immunity study found that chronic MEK signaling increases the metabolic demand on cancer-fighting CD8 T cells, pushing them toward terminal exhaustion in experimental models.
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Cancer & OncologyKRAS mutations drive more than 90% of pancreatic ductal adenocarcinomas (PDAC), yet the protein resisted direct drug development for decades because its surface offered few stable pockets for small molecules and because the mutant protein cycles between active and inactive conformations. That biology is now clinically relevant: a phase 3 trial published in The New […]
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Cell & Molecular BiologyAlexander disease begins with toxic GFAP buildup in astrocytes. Here is how mutations create Rosenthal fibers, disrupt brain support cells, and led to antisense treatment.
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Cell & Molecular BiologyGLP-1 links the gut, pancreas, stomach, and brain. Here is how the pathway controls blood sugar, appetite, gastric emptying, and weight.
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Cell & Molecular BiologyTYK2 and JAK1 help cytokines activate the JAK-STAT pathway. Here is how selective inhibition differs from broader JAK blockade and why it matters in autoimmune disease.
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Cell & Molecular BiologyCells constantly ship messages in nanoscale bubbles — and it's changing medicine.
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